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api 2000 triple quadrupole mass spectrometer  (Thermo Fisher)


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    Thermo Fisher api 2000 triple quadrupole mass spectrometer
    Api 2000 Triple Quadrupole Mass Spectrometer, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/api+2000+triple+quadrupole+mass+spectrometer/pmc11742723-332-10-12
    Average 90 stars, based on 1 article reviews
    api 2000 triple quadrupole mass spectrometer - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Clinical Proteomics:

    Article Title: Dose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat.
    Article Snippet: The aim of this study was to investigate the pharmacokinetic properties of dronedarone by using noncompartmental analysis and modeling approaches after intravenous and oral administration of dronedarone to rats.. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups, and dronedarone was administered intravenously (1 mg/kg) and orally (5, 10, and 40 mg/kg) based on a parallel design.. Blood samples were collected before and 0.083 (intravenous administration only), 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12, and 24 h after drug administration.

    Concentration Assay:

    Article Title: Dose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat.
    Article Snippet: The aim of this study was to investigate the pharmacokinetic properties of dronedarone by using noncompartmental analysis and modeling approaches after intravenous and oral administration of dronedarone to rats.. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups, and dronedarone was administered intravenously (1 mg/kg) and orally (5, 10, and 40 mg/kg) based on a parallel design.. Blood samples were collected before and 0.083 (intravenous administration only), 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12, and 24 h after drug administration.

    High Performance Liquid Chromatography:

    Article Title: Dose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat.
    Article Snippet: The aim of this study was to investigate the pharmacokinetic properties of dronedarone by using noncompartmental analysis and modeling approaches after intravenous and oral administration of dronedarone to rats.. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups, and dronedarone was administered intravenously (1 mg/kg) and orally (5, 10, and 40 mg/kg) based on a parallel design.. Blood samples were collected before and 0.083 (intravenous administration only), 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12, and 24 h after drug administration.

    Article Title: A rapid LC-MS/MS method for simultaneous determination of berberine and irbesartan in rat plasma: Application to the drug-drug pharmacokinetic interaction study after oral administration in rats.
    Article Snippet: Correspondence Qian Liu, Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenhe District, Shenyang 110016, P. R. China.. Email: liuqian@syphu.edu.cn Abstract A sensitive, reproducible, and specific liquid chromatography tandem mass spectrometry method was developed and validated to simultaneously determine the concentration of berberine (BBR) and irbesartan in Sprague–Dawley rat plasma, and applied to study the pharmacokinetic drug–drug interaction (DDI) between BBR and irbesartan in rats.. In this method, diphenhydramine was used as the internal standard, and the liquid–liquid extraction method using ethyl acetate as the extraction agent was used for sample preparation.

    Article Title: Identification of in vitro phase I metabolites of benzotriazole UV stabilizer UV-327 using HPLC coupled with mass spectrometry.
    Article Snippet: The benzotriazole UV stabilizer (BUVS) 2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is used in various plastic products to protect them against harmful UV radiation.. Meanwhile, there are concerns about potential adverse health effects on humans, as residues of UV-327 and other BUVSs have already been detected in various environmental matrices.. However, information on the metabolism of UV-327 is not yet available.

    Targeted Proteomics:

    Article Title: Dose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat.
    Article Snippet: The aim of this study was to investigate the pharmacokinetic properties of dronedarone by using noncompartmental analysis and modeling approaches after intravenous and oral administration of dronedarone to rats.. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups, and dronedarone was administered intravenously (1 mg/kg) and orally (5, 10, and 40 mg/kg) based on a parallel design.. Blood samples were collected before and 0.083 (intravenous administration only), 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12, and 24 h after drug administration.

    Article Title: A rapid LC-MS/MS method for simultaneous determination of berberine and irbesartan in rat plasma: Application to the drug-drug pharmacokinetic interaction study after oral administration in rats.
    Article Snippet: Correspondence Qian Liu, Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenhe District, Shenyang 110016, P. R. China.. Email: liuqian@syphu.edu.cn Abstract A sensitive, reproducible, and specific liquid chromatography tandem mass spectrometry method was developed and validated to simultaneously determine the concentration of berberine (BBR) and irbesartan in Sprague–Dawley rat plasma, and applied to study the pharmacokinetic drug–drug interaction (DDI) between BBR and irbesartan in rats.. In this method, diphenhydramine was used as the internal standard, and the liquid–liquid extraction method using ethyl acetate as the extraction agent was used for sample preparation.

    Article Title: Concentrations of halogenated flame retardants and polychlorinated biphenyls in house dust from Lagos, Nigeria.
    Article Snippet: .. D ow nl oa de d on 2 /2 6/ 20 24 5 :1 6: 50 P M . T hi s ar tic le is li ce ns ed u nd er a C re at iv e C om m on s A ttr ib ut io nN on C om m er ci al 3 .0 U np or te d L ic en ce . was pure helium at a ow rate of 1.5 mL min 1 for both BFRs and PCBs, with the column oven temperature programmes and m/z ions monitored provided in Tables S1 and S2a.† Aer analysis of BFRs and PCBs was complete, the extract was reconstituted in methanol and HBCDDs measured using a dual pump Shimadzu LC-20AB prominence liquid chromatograph (Shimadzu, Kyoto, Japan) interfaced with a Sciex API 2000 triple quadrupole mass spectrometer (Applied Biosystems, Foster City, CA). .. Target HBCDD diastereomers were separated on an Agilent Pursuit XRS3 C18 reversed phase analytical column (150 mm 2 mm i.d., 3 mm particle size).

    Article Title: Templating the 3D structure of conducting polymers with self-assembling peptides.
    Article Snippet: Conducting polymers (CPs) are of great interest in the medical community for their unique electrical properties and tissue compatibility.. Proposed applications of CPs include neural stimulation electrodes, drug delivery systems, artificial muscles, nerve conduits, and engineered tissue scaffolds.. For many of these applications, freestanding CP structures with mechanical properties and 3D architectures similar to native tissues are desired.

    Article Title: Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS
    Article Snippet: .. All mass spectra were collected using an Applied Bio-Systems API 2000 triple quadrupole mass spectrometer (Waltham, Massachusetts) in positive electrospray ionization (ESI+) mode. ..

    Article Title: The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis
    Article Snippet: .. Electrospray ionization (ESI) multiple reaction monitoring (MRM) MS/MS on an API 2000 (Applied Biosystems, Waltham, MA, USA) triple quadrupole mass spectrometer was used for signal detection. ..

    Article Title: Identification of in vitro phase I metabolites of benzotriazole UV stabilizer UV-327 using HPLC coupled with mass spectrometry.
    Article Snippet: The benzotriazole UV stabilizer (BUVS) 2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is used in various plastic products to protect them against harmful UV radiation.. Meanwhile, there are concerns about potential adverse health effects on humans, as residues of UV-327 and other BUVSs have already been detected in various environmental matrices.. However, information on the metabolism of UV-327 is not yet available.

    Article Title: Milk protein digestion and the gut microbiome influence gastrointestinal discomfort after cow milk consumption in healthy subjects.
    Article Snippet: .. The acquisition was performed in negative ion mode on an API 2000 triple quadrupole mass spectrometer (Applied Biosystems, Canada) equipped with a TurboIonSpray source in MRM (Multiple Reaction Monitoring). ..

    Mass Spectrometry:

    Article Title: Dose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat.
    Article Snippet: The aim of this study was to investigate the pharmacokinetic properties of dronedarone by using noncompartmental analysis and modeling approaches after intravenous and oral administration of dronedarone to rats.. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups, and dronedarone was administered intravenously (1 mg/kg) and orally (5, 10, and 40 mg/kg) based on a parallel design.. Blood samples were collected before and 0.083 (intravenous administration only), 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12, and 24 h after drug administration.

    Article Title: Concentrations of halogenated flame retardants and polychlorinated biphenyls in house dust from Lagos, Nigeria.
    Article Snippet: .. D ow nl oa de d on 2 /2 6/ 20 24 5 :1 6: 50 P M . T hi s ar tic le is li ce ns ed u nd er a C re at iv e C om m on s A ttr ib ut io nN on C om m er ci al 3 .0 U np or te d L ic en ce . was pure helium at a ow rate of 1.5 mL min 1 for both BFRs and PCBs, with the column oven temperature programmes and m/z ions monitored provided in Tables S1 and S2a.† Aer analysis of BFRs and PCBs was complete, the extract was reconstituted in methanol and HBCDDs measured using a dual pump Shimadzu LC-20AB prominence liquid chromatograph (Shimadzu, Kyoto, Japan) interfaced with a Sciex API 2000 triple quadrupole mass spectrometer (Applied Biosystems, Foster City, CA). .. Target HBCDD diastereomers were separated on an Agilent Pursuit XRS3 C18 reversed phase analytical column (150 mm 2 mm i.d., 3 mm particle size).

    Article Title: Templating the 3D structure of conducting polymers with self-assembling peptides.
    Article Snippet: Conducting polymers (CPs) are of great interest in the medical community for their unique electrical properties and tissue compatibility.. Proposed applications of CPs include neural stimulation electrodes, drug delivery systems, artificial muscles, nerve conduits, and engineered tissue scaffolds.. For many of these applications, freestanding CP structures with mechanical properties and 3D architectures similar to native tissues are desired.

    Article Title: Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS
    Article Snippet: .. All mass spectra were collected using an Applied Bio-Systems API 2000 triple quadrupole mass spectrometer (Waltham, Massachusetts) in positive electrospray ionization (ESI+) mode. ..

    Article Title: The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis
    Article Snippet: .. Electrospray ionization (ESI) multiple reaction monitoring (MRM) MS/MS on an API 2000 (Applied Biosystems, Waltham, MA, USA) triple quadrupole mass spectrometer was used for signal detection. ..

    Article Title: Identification of in vitro phase I metabolites of benzotriazole UV stabilizer UV-327 using HPLC coupled with mass spectrometry.
    Article Snippet: The benzotriazole UV stabilizer (BUVS) 2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is used in various plastic products to protect them against harmful UV radiation.. Meanwhile, there are concerns about potential adverse health effects on humans, as residues of UV-327 and other BUVSs have already been detected in various environmental matrices.. However, information on the metabolism of UV-327 is not yet available.

    Article Title: Milk protein digestion and the gut microbiome influence gastrointestinal discomfort after cow milk consumption in healthy subjects.
    Article Snippet: .. The acquisition was performed in negative ion mode on an API 2000 triple quadrupole mass spectrometer (Applied Biosystems, Canada) equipped with a TurboIonSpray source in MRM (Multiple Reaction Monitoring). ..

    Tandem Mass Spectroscopy:

    Article Title: The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis
    Article Snippet: .. Electrospray ionization (ESI) multiple reaction monitoring (MRM) MS/MS on an API 2000 (Applied Biosystems, Waltham, MA, USA) triple quadrupole mass spectrometer was used for signal detection. ..



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